This is my new website  8-26-23  I Quit Smoking 18 years ago by taken Acamprosate "Campral" for ringing in my ear, after smoking some 35 years.  Not one Urge to Smoke again   AMAZING   Phone 573-984-934  For More info   

 

ACAMPROSATE is used in the treatment of alcoholism; however, there is little information on its effects on nicotine addiction. The objective of this study was to determine whether acamprosate inhibits cue-induced relapse to nicotine self-administration in the rat. Rats were trained to press a lever to obtain intravenous infusions of nicotine (0.03 mg/kg/infusion) that were associated with the illumination of a cue light. After 29 days of nicotine self-administration sessions, extinction sessions were run during which responses on the active lever did not result in the infusion of nicotine or the illumination of the cue light. After 14 days of extinction sessions the rats received twice-daily injections of saline or acamprosate (50, 100, or 200 mg/kg/intraperitoneally). Seven days later the response to the previously conditioned cue was tested, but only saline infusions were delivered. Pretreatment with all doses of acamprosate reduced responding to a cue previously associated with nicotine. The lowest dose of acamprosate (50 mg/kg) reduced responding for the cue previously associated with nicotine infusions, but had no effect on food-rewarded behavior.   These results show that acamprosate reduced cue-induced nicotine-seeking behavior and suggest that  "ACAMPROSATE MIGHT BE EFFICACIOUS IN TREATING NICOTINE ADDICTION IN HUMANS".                                                                                                                                                                                                                Source: Pechnick RN, Manalo CM, Lacayo LM, Vit JP, Bholat Y, Spivak I, Reyes KC, Farrokhi C. Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center Brain Research Institute, UCLA, Los Angeles, California, USA    June 22, 2011 I received this abstract about 4 years after I quit nicotine with Acamprosate.

 

 

 

 

 

In your opinion do you thing I'm doing the right thing ? -----Original Message----- Date: Fri, 20 May 2011 10:44:58 -0700                                                                                       From: Robert.Pechnick@cshs.org                                                                                                  To: scaler17@hotmail.com Subject:                                                                                                                                                                                                                                                                           RE: Hey Not really.  I am afraid that you are wasting your energy.  I am very happy for you that you were able to stop smoking and I really appreciate your enthusiasm.  But as the writer of one of your e-mails said, modern science is based on what they call "evidence-based" research.  There are a lot of amazing cures reported by people, but they don't hold up when tested in larger groups.  We see this all the time in various ares of medicine, such as people how have experienced remarkable cures for cancer.  The problem is that these "cures" don't always hold up when tested in the general population  Everybody is different in terms of their bodies, their chemistry and individual physiology, diet, life experience, etc.  So drugs have to be tested in large groups of people generate enough evidence to see if the findings hold up.  However, these kinds of trials are very, very expensive, usually costing 10- 100 million dollars!  No drug company is going to pay for that unless they can make a profit on the eventual sales of the drug.  The government, through the National Institutes of Health, might fund some limited studies, but with the current budgetary problems it is very difficult to get grants funded.  I can tell that you are frustrated because it seems like nobody is listening, and for the most part they aren't.  What I would suggest is putting your energy and enthusiasm into posting your experience on boards where people go who are trying to stop smoking.  This way maybe you will help some people who are trying to stop and perhaps find others who have had a similar experience with acamprosate. I will say that your success using acamprosate and enthusiam has inspired my colleagues and I to think about doing additional followup studies.  I have enjoyed our correspondence and I wish you the best of luck.                                                                                                                                                                                                                                                               Robert Pechnick name is on the study above study from Cedars-Sinai   We exchange a few e-mails

 

 

 

 

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